Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8876470 | Journal of Theoretical Biology | 2018 | 20 Pages |
Abstract
A single bystander parameter for each model was fitted to observed average survival of cancer cells in uniform and modulated fields. All models gave better fits than the classical LQ model. Model 2 fitted best with one sign of bystander effect on survival. Model 3 gave the best overall fit of average survival. The models were then used to predict local survival and survival as a function of dose in modulated fields, using independent datasets, without changing the bystander parameter. Model 3 gave the best overall prediction. This study demonstrates that the bystander effect can be controlled by design of the radiation field modulation.
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Authors
Valery Peng, Natalka Suchowerska, Ana Dos Santos Esteves, Linda Rogers, Elizabeth Claridge Mackonis, Joanne Toohey, David R McKenzie,