| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8876704 | Journal of Theoretical Biology | 2018 | 7 Pages |
Abstract
HbA1c is used to estimate average glucose. Previous studies showed linear relationship between average glucose and HbA1c. We made a new theoretical relationship using recently proposed Î-like function model of erythrocyte lifespan. We showed the relationship between average glucose and HbA1c; we approximated it into a simple hyperbolic function: HbA1c=MRBCkgAG/(1+(2/3)MRBCkgAG), whose inverse function is easily obtained. Apparent linear relationship is an approximation of the curved relationship. Hyperbolic function would provide a more accurate approximation than a linear equation. Physicians should keep in mind the curved relationship and be aware that extremely high HbA1c indicates acceleratingly high glucose level.
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Authors
Masashi Kameyama, Sousuke Takeuchi, Shinya Ishii,