Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8883678 | Aquatic Toxicology | 2018 | 9 Pages |
Abstract
Internal effect concentrations of metoprolol and propranolol were in a similar range for all pH-values and for all endpoints. Interestingly, the internal effect concentrations were in the internal concentration range of baseline toxicity, which suggests that the effects of the Ã-blockers are rather unspecific, even for sublethal effects on heart rate. In summary, our data confirm that the pH-dependent toxicity related to external concentrations can be explained by toxicokinetic effects and that the internal effect concentrations are pH-independent.
Related Topics
Life Sciences
Agricultural and Biological Sciences
Aquatic Science
Authors
Lisa Bittner, Elisabet Teixido, Bettina Seiwert, Beate I. Escher, Nils Klüver,