Conversion of carbazole carboxamide based reversible inhibitors of Bruton's tyrosine kinase (BTK) into potent, selective irreversible inhibitors in the carbazole, tetrahydrocarbazole, and a new 2,3-dimethylindole series

Article ID	Journal	Published Year	Pages	File Type
8955025	Bioorganic & Medicinal Chemistry Letters	2018	5 Pages	PDF

Keywords

Btk Bruton’s tyrosine kinase Irreversible inhibitor Carbazole

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Preview

Conversion of carbazole carboxamide based reversible inhibitors of Bruton's tyrosine kinase (BTK) into potent, selective irreversible inhibitors in the carbazole, tetrahydrocarbazole, and a new 2,3-dimethylindole series

Authors

Qingjie Liu, Douglas G. Batt, Charu Chaudhry, Jonathan S. Lippy, Mark A. Pattoli, Neha Surti, Songmei Xu, Percy H. Carter, James R. Burke, Joseph A. Tino,