Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8980813 | Journal of Comparative Pathology | 2005 | 6 Pages |
Abstract
The purpose of this study was to elucidate pathogenesis and viral distribution in pigs infected with swine influenza virus subtype H1N2, over a period of 10 days, by morphometric analysis and in-situ hybridization. Fifteen colostrum-deprived pigs aged 3 weeks were inoculated intranasally with virus. Pneumonia was severe at 1 day post-inoculation (dpi), moderate at 3 and 5Â dpi, and mild at 7 and 10Â dpi. The pulmonary lesion score was correlated with the score of cells positive by in-situ hybridization for swine influenza virus (rs=0.9114, P<0.05). The distribution of swine influenza virus varied according to the duration of infection. At 1 and 3Â dpi, hybridization signals were detected mainly in the bronchial and bronchiolar epithelial cells, but they were detected mainly in the pneumocytes and macrophages (alveolar and interstitial) at 7 and 10Â dpi. The results confirmed that swine influenza virus subtype H1N2, isolated in Korea, is a virulent pathogen causing severe pneumonia.
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Authors
K. Jung, Y. Ha, C. Chae,