Quantitative evaluation of renal function in healthy Beagle puppies and mature dogs

Daily urinary collection and assessment of glomerular filtration rate (GFR) and effective renal plasma flow were performed in ten 2-month-old Beagle puppies and ten 6-9 year-old Beagle dogs to identify age-associated differences in renal function. The most striking differences in puppies compared to mature dogs were a higher daily urinary volume (+65%), GFR (+87%), free water reabsorption (+159%), a lower daily protein excretion (−88%), and fractional excretion of phosphorus (−35%). Renal function in Beagle puppies, but not mature dogs, was also quite different compared to data published in younger adult dogs.