Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8987924 | Veterinary Immunology and Immunopathology | 2005 | 7 Pages |
Abstract
Active infection with bovine herpesvirus-1 (BHV-1) increases the susceptibility of cattle to secondary bacterial pneumonia with Mannheimia (Pasteurella) haemolytica A1. In the present study we found that bovine PMNs incubated with conditioned media from BHV-1 infected peripheral blood mononuclear cells (PBMCs) exhibited increased LFA-1 expression, enhanced LKT binding and increased LKT cytotoxicity. These effects were abrogated when the conditioned medium was pre-incubated with an anti-IL-1β Mab before being added to the PMNs. These findings suggest that BHV-1 infection, and the resulting release of IL-1β and perhaps other inflammatory cytokines, can stimulate activation of LFA-1 in bystander bovine PMNs, thus enhancing the binding and biological effects of LKT.
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Authors
F. Leite, D. Atapattu, C. Kuckleburg, R. Schultz, C.J. Czuprynski,