Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8988749 | The Veterinary Journal | 2005 | 7 Pages |
Abstract
With death as outcome in multivariable models, breed and hospital were significantly associated with outcome but the use of prokinetic agents was not (PÂ =Â 0.15). However, sample size estimates indicate the low power of this study to detect differences in outcome. It was not possible definitively to evaluate the efficacy of prokinetics as treatment for POI following PLO using retrospective data. The data were suggestive of limited efficacy of prokinetics as treatment for POI. It is postulated that the identified association between hospital and survival reflects differences in clinician decision making. The study highlights the need for further prospective studies using randomised clinical trials to evaluate accurately the efficacy of prokinetic agents. This report illustrates difficulties with performing retrospective analysis of clinical data to determine the efficacy of treatment regimes.
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Authors
M.A. Smith, G.B. Edwards, B.L. Dallap, P.J. Cripps, C.J. Proudman,