| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8988835 | The Veterinary Journal | 2005 | 7 Pages |
Abstract
There was no significant correlation between horse age and the proportions of type-IIA and type-IIX MHC isoforms. The percentage of type-I MHC isoforms decreased with advancing age. Muscle citrate synthase activity decreased, whereas lactate dehydrogenase activity increased with increasing age. Muscle 3-OH acyl CoA dehydrogenase activity did not change with ageing. The results suggest that, similar to humans, the oxidative capacity of equine skeletal muscle decreases with age. The age-related changes in muscle metabolic properties appear to be consistent with an age-related transition in MHC isoforms of equine skeletal muscle that shifts toward more glycolytic isoforms with age.
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Authors
Jeong-su Kim, Kenneth W. Hinchcliff, Mamoru Yamaguchi, Laurie A. Beard, Chad D. Markert, Steven T. Devor,