Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9000646 | Experimental and Toxicologic Pathology | 2005 | 10 Pages |
Abstract
Discussion: This study suggests that ICAM-1 has an important pathophysiological role in the response to polymicrobial sepsis. It would appear that absence of this molecule impairs the ability of PMNL to migrate into organ tissues and reduces consequent secondary organ damage resulting in improved clinical status and overall survival. Further investigation into the effectiveness of ICAM-1 modulation in the treatment of sepsis is warranted.
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Authors
Frank Hildebrand, Hans-Christoph Pape, Paul Harwood, Katrin Müller, Petra Hoevel, Claudia Pütz, Arne Siemann, Christian Krettek, Martijn van Griensven,