Un lymphocyte B - un anticorps : le dogme ébranlé

The one B cell-one antibody hypothesis proposed by M.F. Burnet (1957) was recently challenged by results showing that one B cell can simultaneously express an auto-reactive BCR, and a BCR directed against non-self antigens. The latter allows this auto-reactive B cell to escape negative selection. Burnet's theory was thus challenged from the beginning. Namely, Liacopoulos et al. demonstrated that normal B cells produce simultaneously or sequentially two antibody molecules against two unrelated haptens. It thus appears that 'double producers' provide new prospects in auto-immunity. Our previous work using heterologous antigens also suggest that 'double producers' provide an amplifying factor for immunoglobulin repertoire. To cite this article: J. Couderc, C. R. Biologies 328 (2005).