| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9133494 | Infection, Genetics and Evolution | 2005 | 6 Pages |
Abstract
In the current study a method was developed to examine the G/C single nucleotide polymorphism (SNP) at position â174 in the IL-6 promoter from nuclear DNA samples isolated from human skeletal remains from Manitoba, Canada, dating to as early as 3500 years ago. The IL-6 (â174) SNP was detected in three ancient samples and determined, as expected, in three out of three to be homozygous G/G. The analysis of cytokine SNPs of ancient nuclear DNA may provide novel insights into the genetic basis of autoimmune diseases and the susceptibility/resistance to infectious agents.
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Authors
Linda A. Larcombe, Peter Nickerson, Robert D. Hoppa, Carney Matheson,