| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9133511 | Infection, Genetics and Evolution | 2005 | 8 Pages |
Abstract
In three patients, the average frequency of synonymous substitutions (dS) was significantly higher than the nonsynonymous substitutions (dN) whereas in the fourth patient the dN/dS ratio approached the unity. These data demonstrate that negative selective pressure determines the evolution of the HIV-2 env C2-C3 region in vivo. Our results suggest that throughout HIV-2 infection low virus adaptation to strong selective pressures (e.g. immune pressure) promotes the predominance of a few optimally adapted forms.
Related Topics
Life Sciences
Agricultural and Biological Sciences
Ecology, Evolution, Behavior and Systematics
Authors
Helena Barroso, Nuno Taveira,