Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9252765 | Hepatology Research | 2005 | 4 Pages |
Abstract
But simultaneous DFO treatment for one week reduced this elevation of ALT as well as MDA accumulation in the liver. Feeding rats a CDAA diet for 14 weeks led to the development of severe liver fibrosis and preneoplastic lesions detected as enzyme-altered lesions. DFO treatment also prevented the expression of activated stellate cells, resulting in the reduction of liver fibrosis as well as reducing the development of preneoplastic lesions. These results indicate that iron chelation can reduce the development of preneoplastic lesions in a CDAA diet model.
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Authors
Isao Sakaida, Kiwamu Okita,