Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9469586 | Journal of Theoretical Biology | 2005 | 11 Pages |
Abstract
The model shows that when priming and boosting with the same construct, competition rather than cooperation develops amongst T cell clones of different specificities. Moreover, from the simulations, it appears that the sequential use of multiple carriers may generate more robust anti-tumor immune responses and may lead to effective tumor eradication in a higher percentage of cases. Our results provide a rational background for the design of novel strategies for the achievement of immune control of cancer.
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Authors
Filippo Castiglione, Federico Toschi, Massimo Bernaschi, Sauro Succi, Roberta Benedetti, Brunangelo Falini, Arcangelo Liso,