| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 9653458 | Neurocomputing | 2005 | 10 Pages |
Abstract
Recent experimental results have revealed a large diversity of anatomic, synaptic and membrane physiology within the GABAergic system. By incorporating combinations of parametrically varied M-type, A-type, and calcium-dependent potassium (AHP) channels, we were able to replicate in vitro responses to 1-second current steps ranging from 50 to 350Â pA. Our results show the need for subthreshold activating channels to capture the physiological properties of GABAergic cells. Presently underway is a collaboration among the authors to corroborate the proposed channel models using genetic profiles obtained from physiologically characterized interneurons.
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Artificial Intelligence
Authors
James B. Maciokas, Philip Goodman, John Kenyon, Maria Toledo-Rodriguez, Henry Markram,