Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9912481 | European Journal of Cell Biology | 2005 | 13 Pages |
Abstract
Parasite sequestration at microvascular sites is a fundamental phenomenon in the manifestation of the symptoms of malaria and the progression to severe disease. Here, we review the endothelial cell-expressed intercellular adhesion molecule-1 (ICAM-1) and its role in mediating the interaction between the parasitised red blood cell (PRBC) and the vascular endothelium. We highlight the nature of the interaction between ICAM-1 and the parasite-expressed PfEMP-1 molecule at the molecular level. The review also discusses the complexity of the PRBC-endothelial cell interaction and the mechanisms that underlie parasite cytoadherence.
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Authors
Srabasti J. Chakravorty, Alister Craig,