Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
9955353 | Infection, Genetics and Evolution | 2018 | 17 Pages |
Abstract
We determined a complete genome sequence of the Korean field strain, KUMC-62, of human adenovirus type 3 (HAdV-3) and performed comparative genome analyses. Interestingly HAdV-3 has a distinct genomic sequence for the fiber CDS region on average 62.46% of nucleotide sequence identity to other types of HAdV-B1, while remaining genomic region of HAdV-3 is very similar (on average 95.71% of nucleotide sequence identity) to other types of HAdV-B1. The blast results showed that the fiber CDS region of HAdV-3 exhibited the highest nucleotide sequence identity with that of simian adenovirus type 32 (SAdV-32), except other strains of HAdV-3. In the Simplot analysis, a potential recombination event was detected between HAdV-7 and SAdV-32, which might have created HAdV-3 in the past. These findings suggest that HAdV-3 highly likely was created by a natural inter-species recombination event between human and non-human primate AdVs.
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Authors
Ji-Wung Han, Tae-Min La, Ji-Hoon Kim, In-Soo Choi, Chang-Seon Song, Seung-Yong Park, Joong-Bok Lee, Sang-Won Lee,