Alzheimer's disease: Old problem, new views from transgenic and viral models Fulltext Access 11 Pages 2010
Mitochondrial bioenergetics and dynamics interplay in complex I-deficient fibroblasts Fulltext Access 11 Pages 2010
Mouse models of neurological disorders—A comparison of heritable and acquired traits Fulltext Access 11 Pages 2010
Deleterious effects of reactive aldehydes and glycated proteins on macrophage proteasomal function: Possible links between diabetes and atherosclerosis Fulltext Access 11 Pages 2010
Hemoglobin-based oxygen carriers: from mechanisms of toxicity and clearance to rational drug design Fulltext Access 11 Pages 2010
Rheumatoid arthritis progression mediated by activated synovial fibroblasts Fulltext Access 11 Pages 2010
Untranslated regions of thyroid hormone receptor beta 1 mRNA are impaired in human clear cell renal cell carcinoma Fulltext Access 11 Pages 2010
The mitochondrial brain: From mitochondrial genome to neurodegeneration Fulltext Access 11 Pages 2010
Downstream mechanisms triggered by mitochondrial dysfunction in the basal ganglia: From experimental models to neurodegenerative diseases Fulltext Access 11 Pages 2010
The small heat shock protein αA-crystallin is expressed in pancreas and acts as a negative regulator of carcinogenesis Fulltext Access 11 Pages 2010
Genetics of lipid traits: Genome-wide approaches yield new biology and clues to causality in coronary artery disease Fulltext Access 11 Pages 2010
Signaling mechanisms that link salt retention to hypertension: Endogenous ouabain, the Na+ pump, the Na+/Ca2+ exchanger and TRPC proteins Fulltext Access 11 Pages 2010
Therapeutic potential of endothelin receptor antagonists for chronic proteinuric renal disease in humans Fulltext Access 11 Pages 2010
Ubiquitin–proteasome-mediated degradation and synthesis of MyoD is modulated by αB-crystallin, a small heat shock protein, during muscle differentiation Fulltext Access 12 Pages 2010
Acidic stress facilitates tyrosine phosphorylation of HLJ1 to associate with actin cytoskeleton in lung cancer cells Fulltext Access 12 Pages 2010
Human PRP19 interacts with prolyl-hydroxylase PHD3 and inhibits cell death in hypoxia Fulltext Access 12 Pages 2010
MIST1 regulates the pancreatic acinar cell expression of Atp2c2, the gene encoding secretory pathway calcium ATPase 2 Fulltext Access 12 Pages 2010
Activation of microglial cells via protease-activated receptor 2 mediates neuronal cell death in cultured rat primary neuron Fulltext Access 12 Pages 2010
Genome expression profiling and network analysis of nitrite therapy during chronic ischemia: Possible mechanisms and interesting molecules Fulltext Access 12 Pages 2010
Bim is the key mediator of glucocorticoid-induced apoptosis and of its potentiation by rapamycin in human myeloma cells Fulltext Access 12 Pages 2010
Vesicle-associated membrane protein 2 mediates trafficking of α5β1 integrin to the plasma membrane Fulltext Access 12 Pages 2010
ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by γ-secretase Fulltext Access 12 Pages 2010
Fifteen formins for an actin filament: A molecular view on the regulation of human formins Fulltext Access 12 Pages 2010
Endoplasmic reticulum associated protein degradation: A chaperone assisted journey to hell Fulltext Access 12 Pages 2010
Advanced glycation end products inhibit Na+ K+ ATPase in proximal tubule epithelial cells: Role of cytosolic phospholipase A2α and phosphatidylinositol 4-phosphate 5-kinase γ Fulltext Access 12 Pages 2010
Unraveling metalloproteinase function in skeletal biology and disease using genetically altered mice Fulltext Access 12 Pages 2010
Human antiphospholipid antibodies induce TNFα in monocytes via Toll-like receptor 8 Fulltext Access 12 Pages 2010
A single fixation protocol for proteome-wide immunofluorescence localization studies Fulltext Access 12 Pages 2010
Peroxynitrite modifies the structure and function of the extracellular matrix proteoglycan perlecan by reaction with both the protein core and the heparan sulfate chains Fulltext Access 12 Pages 2010
A novel role for caveolin-1 in regulating endothelial nitric oxide synthase activation in response to H2O2 and shear stress Fulltext Access 12 Pages 2010
Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease Fulltext Access 12 Pages 2010
Positively charged amino acids flanking a sumoylation consensus tetramer on the 110Â kDa tri-snRNP component SART1 enhance sumoylation efficiency Fulltext Access 12 Pages 2010
Development and application of mass spectrometric methods for the analysis of progranulin N-glycosylation Fulltext Access 12 Pages 2010
A worm rich in protein: Quantitative, differential, and global proteomics in Caenorhabditis elegans Fulltext Access 12 Pages 2010
Proteogenomics to discover the full coding content of genomes: A computational perspective Fulltext Access 12 Pages 2010
Recommending flavanols and procyanidins for cardiovascular health: Current knowledge and future needs Fulltext Access 12 Pages 2010
Congenital exposure to Schistosoma mansoni infection: Impact on the future immune response and the disease outcome Fulltext Access 12 Pages 2010
Investigation on the anti-tumor efficacy by expression of GPI-anchored mIL-21 on the surface of B16F10 cells in C57BL/6 mice Fulltext Access 12 Pages 2010
Cell density-dependent transcriptional activation of endocrine-related genes in human adipose tissue-derived stem cells Fulltext Access 12 Pages 2010
Serum-derived MHC class II molecules: Potent regulators of the cellular and humoral immune response Fulltext Access 12 Pages 2010
High-dose cyclophosphamide-mediated anti-tumor effects by the superior expansion of CD44high cells after their selective depletion Fulltext Access 12 Pages 2010
Endocannabinoids, FOXO and the metabolic syndrome: Redox, function and tipping point – The view from two systems Fulltext Access 12 Pages 2010
A4D12 monoclonal antibody recognizes a new linear epitope from SAG2A Toxoplasma gondii tachyzoites, identified by phage display bioselection Fulltext Access 12 Pages 2010
Synthesis and evaluation of a technetium-99m labeled cytotoxic bombesin peptide conjugate for targeting bombesin receptor-expressing tumors Fulltext Access 12 Pages 2010
Whole-body biodistribution and brain PET imaging with [18F]AV-45, a novel amyloid imaging agent — a pilot study Fulltext Access 12 Pages 2010
Multispecies animal investigation on biodistribution, pharmacokinetics and toxicity of 177Lu-EDTMP, a potential bone pain palliation agent Fulltext Access 12 Pages 2010
Preparation and in vivo evaluation of radioiodinated closo-decaborate(2-) derivatives to identify structural components that provide low retention in tissues Fulltext Access 12 Pages 2010
RIP4 is a target of multiple signal transduction pathways in keratinocytes: Implications for epidermal differentiation and cutaneous wound repair Fulltext Access 12 Pages 2010
Experimental control of excitable embryonic tissues: three stimuli induce rapid epithelial contraction Fulltext Access 12 Pages 2010
Involvement of ZFPIP/Zfp462 in chromatin integrity and survival of P19 pluripotent cells Fulltext Access 12 Pages 2010
Three dimensional pharmacophore modelling for c-Kit receptor tyrosine kinase inhibitors Fulltext Access 12 Pages 2010
Isoxazole analogs of curcuminoids with highly potent multidrug-resistant antimycobacterial activity Fulltext Access 12 Pages 2010
Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1,2,4-triazole and 1,3,4-oxadiazoles as potential antimicrobial and antitubercular agents Fulltext Access 12 Pages 2010
Synthesis, pharmacological activity and comparative QSAR modeling of 1,5-N,N′-substituted-2-(substituted naphthalenesulphonyl) glutamamides as possible anticancer agents Fulltext Access 12 Pages 2010
Synthesis, characterization and antimicrobial activity of some disubstituted 1,3,4-oxadiazoles carrying 2-(aryloxymethyl)phenyl moiety Fulltext Access 12 Pages 2010
Prenylflavonoids and prenyl/alkyl-phloroacetophenones: Synthesis and antitumour biological evaluation Fulltext Access 12 Pages 2010
Pharmacophore identification and bioactivity prediction for triaminotriazine derivatives by electron conformational-genetic algorithm QSAR method Fulltext Access 12 Pages 2010
1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: Structure–affinity/activity relationship at α1-adrenoceptor subtypes and at 5-HT1A receptors Fulltext Access 12 Pages 2010
Novel three-component domino reactions of ketones, isatin and amino acids: Synthesis and discovery of antimycobacterial activity of highly functionalised novel dispiropyrrolidines Fulltext Access 12 Pages 2010
Chemometric modeling, docking and in silico design of triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors as antimalarials Fulltext Access 12 Pages 2010
Synthesis of aryl phosphates based on pyrimidine and triazine scaffolds Fulltext Access 12 Pages 2010
Synthesis and biological evaluation of some thiazolylpyrazole derivatives as dual anti-inflammatory antimicrobial agents Fulltext Access 12 Pages 2010
Design, synthesis and structure–activity relationship study of novel pyrazole-based heterocycles as potential antitumor agents Fulltext Access 12 Pages 2010
Proteins secreted by embryonic stem cells activate cardiomyocytes through ligand binding pathways Fulltext Access 12 Pages 2010
A centrifugal ultrafiltration strategy for isolating the low-molecular weight (≤ 25 K) component of human plasma proteome Fulltext Access 12 Pages 2010
Proteomics of the response of Arabidopsis thaliana to infection with Alternaria brassicicola Fulltext Access 12 Pages 2010
The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis Fulltext Access 12 Pages 2010
Histone deacetylase 7 (HDAC7) regulates myocyte migration and differentiation Fulltext Access 12 Pages 2010
Mild hyperoxia limits hTR levels, telomerase activity, and telomere length maintenance in hTERT-transduced bone marrow endothelial cells Fulltext Access 12 Pages 2010
The mitochondrial permeability transition pore: A molecular target for amyotrophic lateral sclerosis therapy Fulltext Access 12 Pages 2010
Amyloid fibrillation and cytotoxicity of insulin are inhibited by the amphiphilic surfactants Fulltext Access 12 Pages 2010
Intracellular delivery of full length recombinant human mitochondrial L-Sco2 protein into the mitochondria of permanent cell lines and SCO2 deficient patient's primary cells Fulltext Access 12 Pages 2010
δEF1 promotes breast cancer cell proliferation through down-regulating p21 expression Fulltext Access 12 Pages 2010
Accumulation of polyubiquitylated proteins in response to Ala-Ala-Phe-chloromethylketone is independent of the inhibition of tripeptidyl peptidase II Fulltext Access 12 Pages 2010
Recent advances in the manipulation of murine gene expression and its utility for the study of human neurological disease Fulltext Access 12 Pages 2010
Methadone induces necrotic-like cell death in SH-SY5Y cells by an impairment of mitochondrial ATP synthesis Fulltext Access 12 Pages 2010
Kynurenine inhibits fibroblast growth factor 2-mediated expression of crystallins and MIP26 in lens epithelial cells Fulltext Access 12 Pages 2010
Regulation of the epithelial sodium channel (ENaC) by membrane trafficking Fulltext Access 12 Pages 2010
3D-QSAR studies on quinazoline antifolate thymidylate synthase inhibitors by CoMFA and CoMSIA models Fulltext Access 12 Pages 2010
Synthesis and anti-inflammatory activity of novel (substituted)benzylidene acetone oxime ether derivatives: Molecular modeling study Fulltext Access 12 Pages 2010
Structure–activity relationship studies of acridones as potential antipsoriatic agents. 1. Synthesis and antiproliferative activity of simple N-unsubstituted 10H-acridin-9-ones against human keratinocyte growth Fulltext Access 12 Pages 2010
Permanent positive charge strongly influences DNA/RNA binding and antiproliferative activity of urea–phenanthridinium conjugates Fulltext Access 12 Pages 2010
Synthesis and biological evaluation of dialkylaminoalkylamino benzo[c][1,7] and [1,8]phenanthrolines as antiproliferative agents Fulltext Access 12 Pages 2010
Synthesis and cytotoxicity evaluation of (tetrahydro-β-carboline)-1,3,5-triazine hybrids as anticancer agents Fulltext Access 12 Pages 2010