Engineering a High-Affinity Anti-IL-15 Antibody: Crystal Structure Reveals an α-Helix in VH CDR3 as Key Component of Paratope Fulltext Access 16 Pages 2011
Structure of H/ACA RNP Protein Nhp2p Reveals Cis/Trans Isomerization of a Conserved Proline at the RNA and Nop10 Binding Interface Fulltext Access 16 Pages 2011
HOXC6 Is Transcriptionally Regulated via Coordination of MLL Histone Methylase and Estrogen Receptor in an Estrogen Environment Fulltext Access 16 Pages 2011
Structural and Thermodynamic Signatures of DNA Recognition by Mycobacterium tuberculosis DnaA Fulltext Access 16 Pages 2011
Mapping of DNA Binding Sites in the Tetrahymena Telomerase Holoenzyme Proteins by UV Cross-Linking and Mass Spectrometry Fulltext Access 16 Pages 2011
Interaction of Human 3-Phosphoglycerate Kinase with Its Two Substrates: Is Substrate Antagonism a Kinetic Advantage? Fulltext Access 16 Pages 2011
Crystal Structures and Enzymatic Properties of a Triamine/Agmatine Aminopropyltransferase from Thermus thermophilus Fulltext Access 16 Pages 2011
Homology Model of the Na+/Proline Transporter PutP of Escherichia coli and Its Functional Implications Fulltext Access 16 Pages 2011
Cooperative RNP Assembly: Complementary Rescue of Structural Defects by Protein and RNA Subunits of Archaeal RNase P Fulltext Access 16 Pages 2011
Differential Interactions of Fluorescent Agonists and Antagonists with the Yeast G Protein Coupled Receptor Ste2p Fulltext Access 16 Pages 2011
The NMR Structure of FliK, the Trigger for the Switch of Substrate Specificity in the Flagellar Type III Secretion Apparatus Fulltext Access 16 Pages 2011
Highly Stable Binding Proteins Derived from the Hyperthermophilic Sso7d Scaffold Fulltext Access 16 Pages 2011
Active Mutants of the TCR-Mediated p38α Alternative Activation Site Show Changes in the Phosphorylation Lip and DEF Site Formation Fulltext Access 16 Pages 2011
iWRAP: An Interface Threading Approach with Application to Prediction of Cancer-Related Protein–Protein Interactions Fulltext Access 16 Pages 2011
Detection and Characterization of the In Vitro E3 Ligase Activity of the Human MID1 Protein Fulltext Access 16 Pages 2011
Structural Analysis of an Equilibrium Folding Intermediate in the Apoflavodoxin Native Ensemble by Small-Angle X-ray Scattering Fulltext Access 16 Pages 2011
Ab initio and semi-empirical computational studies on 5-hydroxy-4-methyl-5,6-di-pyridin-2-yl-4,5-dihydro-2H-[1,2,4]triazine-3-thione Fulltext Access 16 Pages 2011
Comparative vibrational spectroscopic studies, HOMO–LUMO and NBO analysis of 5,7-dibromo-8-hydroxyquinoline and 5,7-dichloro-8-hydroxyquinoline based on Density Functional Theory Fulltext Access 16 Pages 2011
A diffusion gradient optimization framework for spinal cord diffusion tensor imaging Fulltext Access 16 Pages 2011
Fixed-point algorithms for constrained ICA and their applications in fMRI data analysis Fulltext Access 16 Pages 2011
Chromatin-Associated Protein Kinase C-θ Regulates an Inducible Gene Expression Program and MicroRNAs in Human T Lymphocytes Fulltext Access 16 Pages 2011
Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome Fulltext Access 16 Pages 2011
Thermodynamics and Kinetics of the Hairpin Ribozyme from Atomistic Folding/Unfolding Simulations Fulltext Access 17 Pages 2011
Flexible Nature and Specific Functions of the HIV-1 Nucleocapsid Protein Fulltext Access 17 Pages 2011
Mechanism of Host Cell MAPK/ERK-2 Incorporation into Lentivirus Particles: Characterization of the Interaction between MAPK/ERK-2 and Proline-Rich-Domain Containing Capsid Region of Structural Protein Gag Fulltext Access 17 Pages 2011
A Proteasome Assembly Defect in rpn3 Mutants Is Associated with Rpn11 Instability and Increased Sensitivity to Stress Fulltext Access 17 Pages 2011
Fluid and Condensed ApoA-I/Phospholipid Monolayers Provide Insights into ApoA-I Membrane Insertion Fulltext Access 17 Pages 2011
Crystal Structure of the Plant Epigenetic Protein Arginine Methyltransferase 10 Fulltext Access 17 Pages 2011
Molecular Determinants and Thermodynamics of the Amyloid Precursor Protein Transmembrane Domain Implicated in Alzheimer's Disease Fulltext Access 17 Pages 2011
The Crystal Structure of Cupriavidus necator Nitrate Reductase in Oxidized and Partially Reduced States Fulltext Access 17 Pages 2011
BRCA1 Is Required for Postreplication Repair after UV-Induced DNA Damage Fulltext Access 17 Pages 2011
Substrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6 Fulltext Access 17 Pages 2011
Classification and Annotation of the Relationship between Protein Structural Change and Ligand Binding Fulltext Access 17 Pages 2011
Unsupervised MRI segmentation of brain tissues using a local linear model and level set Fulltext Access 17 Pages 2011
Segmental Conformational Disorder and Dynamics in the Intrinsically Disordered Protein α-Synuclein and Its Chain Length Dependence Fulltext Access 17 Pages 2011
Structural Signatures of Enzyme Binding Pockets from Order-Independent Surface Alignment: A Study of Metalloendopeptidase and NAD Binding Proteins Fulltext Access 17 Pages 2011
Mechanism of Binding Site Conformational Switching in the CD44–Hyaluronan Protein–Carbohydrate Binding Interaction Fulltext Access 17 Pages 2011
plusTipTracker: Quantitative image analysis software for the measurement of microtubule dynamics Fulltext Access 17 Pages 2011
Mapping the Deltex-Binding Surface on the Notch Ankyrin Domain Using Analytical Ultracentrifugation Fulltext Access 17 Pages 2011
Comparison of SARS and NL63 Papain-Like Protease Binding Sites and Binding Site Dynamics: Inhibitor Design Implications Fulltext Access 17 Pages 2011
Focal Adhesion Proteins Talin-1 and Vinculin Negatively Affect Paxillin Phosphorylation and Limit Retroviral Infection Fulltext Access 17 Pages 2011
Autophosphorylation in the Leucine-Rich Repeat Kinase 2 (LRRK2) GTPase Domain Modifies Kinase and GTP-Binding Activities Fulltext Access 17 Pages 2011
Structure-Based Design of a Protein Immunogen that Displays an HIV-1 gp41 Neutralizing Epitope Fulltext Access 17 Pages 2011
Different Requirements for σ Region 4 in BvgA Activation of the Bordetella pertussis Promoters Pfim3 and PfhaB Fulltext Access 18 Pages 2011
Structural and Functional Impact of Cancer-Related Missense Somatic Mutations Fulltext Access 18 Pages 2011
A Molecular Model of Phosphorylation-Based Activation and Potentiation of Tarantula Muscle Thick Filaments Fulltext Access 18 Pages 2011
DARPins Recognizing the Tumor-Associated Antigen EpCAM Selected by Phage and Ribosome Display and Engineered for Multivalency Fulltext Access 18 Pages 2011
Single-Molecule Studies of Transcription: From One RNA Polymerase at a Time to the Gene Expression Profile of a Cell Fulltext Access 18 Pages 2011
Congeneric but Still Distinct: How Closely Related Trypsin Ligands Exhibit Different Thermodynamic and Structural Properties Fulltext Access 18 Pages 2011
Proteomic Characterization of Archaeal Ribosomes Reveals the Presence of Novel Archaeal-Specific Ribosomal Proteins Fulltext Access 18 Pages 2011
Mechanism of Bacterial Transcription Initiation: RNA Polymerase - Promoter Binding, Isomerization to Initiation-Competent Open Complexes, and Initiation of RNA Synthesis Fulltext Access 18 Pages 2011
A study of quantum phase transitions and quantum monodromy in the bending motion of non-rigid molecules Fulltext Access 18 Pages 2011
Molecular Links between the E2 Envelope Glycoprotein and Nucleocapsid Core in Sindbis Virus Fulltext Access 18 Pages 2011
Spectroscopic studies, thermal analyses and biological evaluation of new V(IV), Zr(IV) and U(VI) moxifloxacin complexes Fulltext Access 18 Pages 2011
The Human Mitochondrial tRNAMet: Structure/Function Relationship of a Unique Modification in the Decoding of Unconventional Codons Fulltext Access 18 Pages 2011
Structural Studies of ROK Fructokinase YdhR from Bacillus subtilis: Insights into Substrate Binding and Fructose Specificity Fulltext Access 18 Pages 2011
A Repeated Coiled-Coil Interruption in the Escherichiacoli Condensin MukB Fulltext Access 18 Pages 2011
RGK Family G-Domain:GTP Analog Complex Structures and Nucleotide-Binding Properties Fulltext Access 18 Pages 2011
Complete Modification Maps for the Cytosolic Small and Large Subunit rRNAs of Euglena gracilis: Functional and Evolutionary Implications of Contrasting Patterns between the Two rRNA Components Fulltext Access 18 Pages 2011
HuCAL PLATINUM, a Synthetic Fab Library Optimized for Sequence Diversity and Superior Performance in Mammalian Expression Systems Fulltext Access 18 Pages 2011
The TβR-I Pre-Helix Extension Is Structurally Ordered in the Unbound Form and Its Flanking Prolines Are Essential for Binding Fulltext Access 18 Pages 2011
The Alternating-Access Mechanism of MFS Transporters Arises from Inverted-Topology Repeats Fulltext Access 18 Pages 2011
Functional Recognition of the Modified Human tRNALys3UUU Anticodon Domain by HIV's Nucleocapsid Protein and a Peptide Mimic Fulltext Access 18 Pages 2011
In Vitro Affinity Maturation of an Anti-PSA Antibody for Prostate Cancer Diagnostic Assay Fulltext Access 18 Pages 2011
Predicting Knot and Catenane Type of Products of Site-Specific Recombination on Twist Knot Substrates Fulltext Access 18 Pages 2011
Design of in Vitro Symmetric Complexes and Analysis by Hybrid Methods Reveal Mechanisms of HIV Capsid Assembly Fulltext Access 19 Pages 2011
Dynamics of Preferential Substrate Recognition in HIV-1 Protease: Redefining the Substrate Envelope Fulltext Access 19 Pages 2011
Cooperation of the Prolyl Isomerase and Chaperone Activities of the Protein Folding Catalyst SlyD Fulltext Access 19 Pages 2011
Palladium(II) and platinum(II) complexes containing benzimidazole ligands: Molecular structures, vibrational frequencies and cytotoxicity Fulltext Access 19 Pages 2011
The Structural and Dynamic Response of MAGI-1 PDZ1 with Noncanonical Domain Boundaries to the Binding of Human Papillomavirus E6 Fulltext Access 19 Pages 2011
NMR Characterisation of the Relationship between Frustration and the Excited State of Im7 Fulltext Access 19 Pages 2011
ReviewThe Effects of Replication Stress on S Phase Histone Management and Epigenetic Memory Fulltext Access 19 Pages 2011
Facioscapulohumeral Muscular Dystrophy Region Gene 1 Is a Dynamic RNA-Associated and Actin-Bundling Protein Fulltext Access 20 Pages 2011
The Overall Architecture and Receptor Binding of Pneumococcal Carbohydrate-Antigen-Hydrolyzing Enzymes Fulltext Access 20 Pages 2011
Molecular Insights into the Control of Transcription Initiation at the Staphylococcus aureus agr operon Fulltext Access 20 Pages 2011
Chlorite Dismutases, DyPs, and EfeB: 3 Microbial Heme Enzyme Families Comprise the CDE Structural Superfamily Fulltext Access 20 Pages 2011
The Conformation and Orientation of a 27-Residue CCR5 Peptide in a Ternary Complex with HIV-1 gp120 and a CD4-Mimic Peptide Fulltext Access 20 Pages 2011
In Vitro DNA Tethering of HIV-1 Integrase by the Transcriptional Coactivator LEDGF/p75 Fulltext Access 20 Pages 2011
The Monomeric, Tetrameric, and Fibrillar Organization of Fib: The Dynamic Building Block of the Bacterial Linear Motor of Spiroplasma melliferum BC3 Fulltext Access 20 Pages 2011
A Polypeptide “Building Block” for the β-Trefoil Fold Identified by “Top-Down Symmetric Deconstruction” Fulltext Access 20 Pages 2011
A Structural Model for Apolipoprotein C-II Amyloid Fibrils: Experimental Characterization and Molecular Dynamics Simulations Fulltext Access 21 Pages 2011
A statistical examination of SENSE image reconstruction via an isomorphism representation Fulltext Access 21 Pages 2011
Tailoring and histochemical application of fluorescent homo-dimeric styryl dyes using frozen sections: From peroxidase substrates to new cytochemical probes for mast cells, keratin, cartilage and nucleic acids Fulltext Access 21 Pages 2011
T-Cell Receptor Signaling Enhances Transcriptional Elongation from Latent HIV Proviruses by Activating P-TEFb through an ERK-Dependent Pathway Fulltext Access 21 Pages 2011
Analyses of the Functional Regions of DEAD-Box RNA “Helicases” with Deletion and Chimera Constructs Tested In Vivo and In Vitro Fulltext Access 22 Pages 2011
Impairment of Ubiquitin–Proteasome System by E334K cMyBPC Modifies Channel Proteins, Leading to Electrophysiological Dysfunction Fulltext Access 22 Pages 2011
Probing the Determinants of Diacylglycerol Binding Affinity in the C1B Domain of Protein Kinase Cα Fulltext Access 22 Pages 2011
Optimization of the In-Silico-Designed Kemp Eliminase KE70 by Computational Design and Directed Evolution Fulltext Access 22 Pages 2011