Asymmetry in Membrane Protein Sequence and Structure: Glycine Outside Rule Fulltext Access 9 Pages 2008
Visualization of the eEF2–80S Ribosome Transition-State Complex by Cryo-Electron Microscopy Fulltext Access 9 Pages 2008
Down-regulation of Outer Membrane Proteins by Noncoding RNAs: Unraveling the cAMP–CRP- and σE-Dependent CyaR–ompX Regulatory Case Fulltext Access 9 Pages 2008
Aromatic Cross-Strand Ladders Control the Structure and Stability of β-Rich Peptide Self-Assembly Mimics Fulltext Access 9 Pages 2008
Cofilin Increases the Bending Flexibility of Actin Filaments: Implications for Severing and Cell Mechanics Fulltext Access 9 Pages 2008
Incorporation of the Arc1p tRNA-Binding Domain to the Catalytic Core of MetRS Can Functionally Replace the Yeast Arc1p–MetRS Complex Fulltext Access 9 Pages 2008
Concerted Release of Substrate Domains from GroEL by ATP Is Demonstrated with FRET Fulltext Access 9 Pages 2008
The Cys154 → Gly Mutation in LacY Causes Constitutive Opening of the Hydrophilic Periplasmic Pathway Fulltext Access 9 Pages 2008
Crystal Structure of a Cellulosomal Family 3 Carbohydrate Esterase from Clostridium thermocellum Provides Insights into the Mechanism of Substrate Recognition Fulltext Access 9 Pages 2008
Ring-Opening Mechanism Revealed by Crystal Structures of NagB and Its ES Intermediate Complex Fulltext Access 9 Pages 2008
Crystal Structure at 2.8 Å of Huntingtin-Interacting Protein 1 (HIP1) Coiled-Coil Domain Reveals a Charged Surface Suitable for HIP1 Protein Interactor (HIPPI) Fulltext Access 9 Pages 2008
An ADP/ATP-Specific Mitochondrial Carrier Protein in the Microsporidian Antonospora locustae Fulltext Access 9 Pages 2008
Examining the Dynamic Energy Landscape of an Antiporter upon Inhibitor Binding Fulltext Access 9 Pages 2008
Structural Basis for the Interaction between Focal Adhesion Kinase and CD4 Fulltext Access 9 Pages 2008
Cryo-Electron Microscopy Structure of a Yeast Mitochondrial Preprotein Translocase Fulltext Access 9 Pages 2008
Structure of a Widely Conserved Type IV Pilus Biogenesis Factor that Affects the Stability of Secretin Multimers Fulltext Access 9 Pages 2008
The Crystal Structure of Guamerin in Complex with Chymotrypsin and the Development of an Elastase-specific Inhibitor Fulltext Access 9 Pages 2008
Stabilizing Ionic Interactions in a Full-consensus Ankyrin Repeat Protein Fulltext Access 9 Pages 2008
Torque–Speed Relationships of Na+-driven Chimeric Flagellar Motors in Escherichia coli Fulltext Access 9 Pages 2008
Hydrodynamic Studies on Defined Heterochromatin Fragments Support a 30-nm Fiber Having Six Nucleosomes per Turn Fulltext Access 9 Pages 2008
A Facile Reporter System for the Experimental Identification of Twin-Arginine Translocation (Tat) Signal Peptides from All Kingdoms of Life Fulltext Access 9 Pages 2008
Spectral Characteristics of the Photocycle of Channelrhodopsin-2 and Its Implication for Channel Function Fulltext Access 9 Pages 2008
Predicting the Magnitude of the Reflex Response to Insertions in Ubiquitin Fulltext Access 9 Pages 2008
Malarial EBA-175 Region VI Crystallographic Structure Reveals a KIX-Like Binding Interface Fulltext Access 9 Pages 2008
Functional Intracellular Antibody Fragments Do Not Require Invariant Intra-domain Disulfide Bonds Fulltext Access 9 Pages 2008
How Do Chemical Denaturants Affect the Mechanical Folding and Unfolding of Proteins? Fulltext Access 9 Pages 2008
New Insights into the Autoinhibition Mechanism of Glycogen Synthase Kinase-3β Fulltext Access 9 Pages 2008
Experimental Evidence for the Existence of a Stable Half-Barrel Subdomain in the (β/α)8-Barrel Fold Fulltext Access 9 Pages 2008
Truncated Cockayne Syndrome B Protein Represses Elongation by RNA Polymerase I Fulltext Access 9 Pages 2008
The Novel Protein Complex with SMARCAD1/KIAA1122 Binds to the Vicinity of TSS Fulltext Access 9 Pages 2008
Friedreich's Ataxia GAA·TTC Duplex and GAA·GAA·TTC Triplex Structures Exclude Nucleosome Assembly Fulltext Access 9 Pages 2008
Folding and Membrane Insertion of the Pore-Forming Peptide Gramicidin Occur as a Concerted Process Fulltext Access 9 Pages 2008
The High-Resolution NMR Structure of the Early Folding Intermediate of the Thermus thermophilus Ribonuclease H Fulltext Access 9 Pages 2008
An Intrinsic Degradation Tag on the ClpA C-Terminus Regulates the Balance of ClpAP Complexes with Different Substrate Specificity Fulltext Access 9 Pages 2008
The Crystal Structure of JNK2 Reveals Conformational Flexibility in the MAP Kinase Insert and Indicates Its Involvement in the Regulation of Catalytic Activity Fulltext Access 9 Pages 2008
Ligand Recognition by ActR, a TetR-Like Regulator of Actinorhodin Export Fulltext Access 9 Pages 2008
Structure of Antibody F425-B4e8 in Complex with a V3 Peptide Reveals a New Binding Mode for HIV-1 Neutralization Fulltext Access 10 Pages 2008
Structural and Molecular Characterization of the Prefoldin β Subunit from Thermococcus Strain KS-1 Fulltext Access 10 Pages 2008
Crystal-Structure and Biochemical Characterization of Recombinant Human Calcyphosine Delineates a Novel EF-Hand-Containing Protein Family Fulltext Access 10 Pages 2008
An Unstable Head–Rod Junction May Promote Folding into the Compact Off-State Conformation of Regulated Myosins Fulltext Access 10 Pages 2008
Upstream Stimulatory Factors Regulate OSCAR Gene Expression in RANKL-Mediated Osteoclast Differentiation Fulltext Access 10 Pages 2008
Crystal Structure of a Minimal Nitroreductase, ydjA, from Escherichia coli K12 with and without FMN Cofactor Fulltext Access 10 Pages 2008
Specific Heteromeric Association of Four Transmembrane Peptides Derived from Platelet Glycoprotein Ib–IX Complex Fulltext Access 10 Pages 2008
Multiparametric Fluorescence Detection of Early Stages in the Amyloid Protein Aggregation of Pyrene-labeled α-Synuclein Fulltext Access 10 Pages 2008
Porphyrin Binding and Distortion and Substrate Specificity in the Ferrochelatase Reaction: The Role of Active Site Residues Fulltext Access 10 Pages 2008
The Recognition Domain of the BpuJI Restriction Endonuclease in Complex with Cognate DNA at 1.3-Å Resolution Fulltext Access 10 Pages 2008
Improvement of an Antibody Neutralizing the Anthrax Toxin by Simultaneous Mutagenesis of Its Six Hypervariable Loops Fulltext Access 10 Pages 2008
Implications of the Progressive Self-association of Wild-type Human Factor H for Complement Regulation and Disease Fulltext Access 10 Pages 2008
Active Transcription is Required for Maintenance of Epigenetic Memory in the Malaria Parasite Plasmodium falciparum Fulltext Access 10 Pages 2008
Stability of Dimer and Domain–Domain Interaction of Arabidopsis Phototropin 1 LOV2 Fulltext Access 10 Pages 2008
A β-Hairpin Comprising the Nuclear Localization Sequence Sustains the Self-associated States of Nucleosome Assembly Protein 1 Fulltext Access 10 Pages 2008
Epistatic Interaction Between the K-Homology Domain Protein HEK2 and SIR1 at HMR and Telomeres in Yeast Fulltext Access 10 Pages 2008
K+/Na+ Selectivity in K Channels and Valinomycin: Over-coordination Versus Cavity-size constraints Fulltext Access 10 Pages 2008
Changes in the Molecular Packing of Fibrillin Microfibrils During Extension Indicate Intrafibrillar and Interfibrillar Reorganization in Elastic Response Fulltext Access 10 Pages 2008
Invasion of Tumorigenic HT1080 Cells Is Impeded by Blocking or Downregulating the 37-kDa/67-kDa Laminin Receptor Fulltext Access 10 Pages 2008
Interplay between DNA Polymerase and Proliferating Cell Nuclear Antigen Switches Off Base Excision Repair of Uracil and Hypoxanthine during Replication in Archaea Fulltext Access 10 Pages 2008
Assessing Side-Chain Perturbations of the Protein Backbone: A Knowledge-Based Classification of Residue Ramachandran Space Fulltext Access 10 Pages 2008
Structural Characteristics of α-Synuclein Oligomers Stabilized by the Flavonoid Baicalein Fulltext Access 10 Pages 2008
30 nm Chromatin Fibre Decompaction Requires both H4-K16 Acetylation and Linker Histone Eviction Fulltext Access 10 Pages 2008
Structural and Mutational Analyses of the Interaction between the Barley α-Amylase/Subtilisin Inhibitor and the Subtilisin Savinase Reveal a Novel Mode of Inhibition Fulltext Access 10 Pages 2008
Congruence of inVivo and in Vitro Insertion Patterns in Hot E. coli Gene Targets of Transposable Element Mu: Opposing Roles of MuB in Target Capture and Integration Fulltext Access 10 Pages 2008
A Mechanistic Insight into SMAC Peptide Interference with XIAP-Bir2 Inhibition of Executioner Caspases Fulltext Access 10 Pages 2008
Blockade of NF-κB Using IκBα Dominant-Negative Mice Ameliorates Cardiac Hypertrophy in Myotrophin-Overexpressed Transgenic Mice Fulltext Access 10 Pages 2008
Hyperphosphorylation of RNA Polymerase II in Response to Topoisomerase I Cleavage Complexes and Its Association with Transcription- and BRCA1-dependent Degradation of Topoisomerase I Fulltext Access 10 Pages 2008
Similarities and Differences between Frozen-Hydrated, Rigor Acto–S1 Complexes of Insect Flight and Chicken Skeletal Muscles Fulltext Access 10 Pages 2008
Exploring the Limits of Sequence and Structure in a Variant βγ-Crystallin Domain of the Protein Absent in Melanoma-1 (AIM1) Fulltext Access 10 Pages 2008
Solution Structure of the Inner DysF Domain of Myoferlin and Implications for Limb Girdle Muscular Dystrophy Type 2B Fulltext Access 10 Pages 2008
Analysis of the Isolated SecA DEAD Motor Suggests a Mechanism for Chemical–Mechanical Coupling Fulltext Access 10 Pages 2008
Tyrosine Phosphorylation in the SH3 Domain Disrupts Negative Regulatory Interactions within the c-Abl Kinase Core Fulltext Access 10 Pages 2008
Ribosome Collisions and Translation Efficiency: Optimization by Codon Usage and mRNA Destabilization Fulltext Access 10 Pages 2008
Subnanometer-Resolution Structures of the Grass Carp Reovirus Core and Virion Fulltext Access 10 Pages 2008
Non-random-coil Behavior as a Consequence of Extensive PPII Structure in the Denatured State Fulltext Access 10 Pages 2008
A Nested Gene in Streptomyces Bacteria Encodes a Protein Involved in Quaternary Complex Formation Fulltext Access 10 Pages 2008
Substrate Recognition Mechanism of α-1,6-Glucosidic Linkage Hydrolyzing Enzyme, Dextran Glucosidase from Streptococcus mutans Fulltext Access 10 Pages 2008
Crystal Structure of the Peptidoglycan Recognition Protein at 1.8 Å Resolution Reveals Dual Strategy to Combat Infection Through Two Independent Functional Homodimers Fulltext Access 10 Pages 2008
Determination of the Physiological Dimer Interface of the PhoQ Sensor Domain Fulltext Access 10 Pages 2008
Cotranslational Folding Promotes β-Helix Formation and Avoids Aggregation In Vivo Fulltext Access 10 Pages 2008
Configurational Entropy Modulates the Mechanical Stability of Protein GB1 Fulltext Access 10 Pages 2008
Histone H3K4me3 Binding Is Required for the DNA Repair and Apoptotic Activities of ING1 Tumor Suppressor Fulltext Access 10 Pages 2008
Structure of an Fab–Protease Complex Reveals a Highly Specific Non-canonical Mechanism of Inhibition Fulltext Access 10 Pages 2008
Design of Protein–Ligand Binding Based on the Molecular-Mechanics Energy Model Fulltext Access 10 Pages 2008
Unusual Role of a Cysteine Residue in Substrate Binding and Activity of Human AP-Endonuclease 1 Fulltext Access 10 Pages 2008
The Crystal Structure of the C-Terminal DAP5/p97 Domain Sheds Light on the Molecular Basis for Its Processing by Caspase Cleavage Fulltext Access 10 Pages 2008
Roles of the Minor Capsid Protein P7 in the Assembly and Replication of Double-Stranded RNA Bacteriophage ϕ6 Fulltext Access 10 Pages 2008
Contribution of Ser386 and Ser396 to Activation of Interferon Regulatory Factor 3 Fulltext Access 10 Pages 2008
Functional Analysis of Kv1.2 and Paddle Chimera Kv Channels in Planar Lipid Bilayers Fulltext Access 10 Pages 2008