Exploring the Capacity of Minimalist Protein Interfaces: Interface Energetics and Affinity Maturation to Picomolar KD of a Single-domain Antibody with a Flat Paratope Fulltext Access 13 Pages 2007
The Highly Reduced and Fragmented Mitochondrial Genome of the Early-branching Dinoflagellate Oxyrrhis marina Shares Characteristics with both Apicomplexan and Dinoflagellate Mitochondrial Genomes Fulltext Access 13 Pages 2007
Haloferax volcanii AglB and AglD are Involved in N-glycosylation of the S-layer Glycoprotein and Proper Assembly of the Surface Layer Fulltext Access 13 Pages 2007
Molecular and Functional Mapping of EED Motifs Required for PRC2-Dependent Histone Methylation Fulltext Access 13 Pages 2007
Spackling the Crack: Stabilizing Human Fibroblast Growth Factor-1 by Targeting the N and C terminus β-Strand Interactions Fulltext Access 13 Pages 2007
Crystal Structure of Bovine Lipoyltransferase in Complex with Lipoyl-AMP Fulltext Access 13 Pages 2007
Adenosine 5′-O-(3-thio)triphosphate (ATPγS) Promotes Positive Supercoiling of DNA by T. maritima Reverse Gyrase Fulltext Access 13 Pages 2007
A Dual-nuclease Mechanism for DNA Break Processing by AddAB-type Helicase-nucleases Fulltext Access 13 Pages 2007
Nitration of a Critical Tyrosine Residue in the Allosteric Inhibitor Site of Muscle Glycogen Phosphorylase Impairs its Catalytic Activity Fulltext Access 13 Pages 2007
Analysis of Structural Dynamics in the Ribosome by TLS Crystallographic Refinement Fulltext Access 13 Pages 2007
Biochemical and Structural Characterization of the Paralogous Benzoate CoA Ligases from Burkholderia xenovorans LB400: Defining the Entry Point into the Novel Benzoate Oxidation (box) Pathway Fulltext Access 13 Pages 2007
Active and Exo-site Inhibition of Human Factor Xa: Structure of des-Gla Factor Xa Inhibited by NAP5, a Potent Nematode Anticoagulant Protein from Ancylostoma caninum Fulltext Access 13 Pages 2007
Folding Mechanism of an Ankyrin Repeat Protein: Scaffold and Active Site Formation of Human CDK Inhibitor p19INK4d Fulltext Access 13 Pages 2007
R-subunit Isoform Specificity in Protein Kinase A: Distinct Features of Protein Interfaces in PKA Types I and II by Amide H/2H Exchange Mass Spectrometry Fulltext Access 13 Pages 2007
Articular cartilage and growth plate defects are associated with chondrocyte cytoskeletal abnormalities in Tg737orpk mice lacking the primary cilia protein polaris Fulltext Access 13 Pages 2007
Differences in matrix accumulation and hypertrophy in superficial and deep zone chondrocytes are controlled by bone morphogenetic protein Fulltext Access 13 Pages 2007
The Structural Coupling between ATPase Activation and Recovery Stroke in the Myosin II Motor Fulltext Access 13 Pages 2007
Ensemble Refinement of Protein Crystal Structures: Validation and Application Fulltext Access 13 Pages 2007
Synaptic Arrangement of the Neuroligin/β-Neurexin Complex Revealed by X-Ray and Neutron Scattering Fulltext Access 13 Pages 2007
Distinct Structural Mechanisms for Inhibition of Pyruvate Dehydrogenase Kinase Isoforms by AZD7545, Dichloroacetate, and Radicicol Fulltext Access 13 Pages 2007
Ligand-Induced Structural Transitions in ErbB Receptor Extracellular Domains Fulltext Access 13 Pages 2007
Biochemical Implications of a Three-Dimensional Model of Monomeric Actin Bound to Magnesium-Chelated ATP Fulltext Access 13 Pages 2007
Identification of Secondary Structure Elements in Intermediate-Resolution Density Maps Fulltext Access 13 Pages 2007
Mechanism for De Novo RNA Synthesis and Initiating Nucleotide Specificity by T7 RNA Polymerase Fulltext Access 13 Pages 2007
A Structural Comparison of Inhibitor Binding to PKB, PKA and PKA-PKB Chimera Fulltext Access 13 Pages 2007
An Envelope-determined Endocytic Route of Viral Entry Allows HIV-1 to Escape from Secreted Phospholipase A2 Entry Blockade Fulltext Access 13 Pages 2007
Structure of a Complex of Human Lactoferrin N-lobe with Pneumococcal Surface Protein A Provides Insight into Microbial Defense Mechanism Fulltext Access 13 Pages 2007
c-Abl-binding Protein Interacts with p21-activated Kinase 2 (PAK-2) to Regulate PDGF-induced Membrane Ruffles Fulltext Access 13 Pages 2007
Effects of Osmolytes on RNA Secondary and Tertiary Structure Stabilities and RNA-Mg2+ Interactions Fulltext Access 13 Pages 2007
Crystal Structure of Medicago truncatula UGT85H2 – Insights into the Structural Basis of a Multifunctional (Iso)flavonoid Glycosyltransferase Fulltext Access 13 Pages 2007
The Role of a Hydrogen Bonding Network in the Transmembrane β-Barrel OMPLA Fulltext Access 13 Pages 2007
Structure and Mechanism of HpcG, a Hydratase in the Homoprotocatechuate Degradation Pathway of Escherichia coli Fulltext Access 13 Pages 2007
Molecular Basis of Bcl-xL’s Target Recognition Versatility Revealed by the Structure of Bcl-xL in Complex with the BH3 Domain of Beclin-1 Fulltext Access 13 Pages 2007
Structure and Evolutionary Analysis of a Non-biological ATP-binding Protein Fulltext Access 13 Pages 2007
Changes in Apparent Free Energy of Helix–Helix Dimerization in a Biological Membrane Due to Point Mutations Fulltext Access 13 Pages 2007
M-LDH Serves as a Regulatory Subunit of the Cytosolic Substrate-channelling Complex in Vivo Fulltext Access 13 Pages 2007
Directional Loading and Stimulation of PcrA Helicase by the Replication Initiator Protein RepD Fulltext Access 13 Pages 2007
Effects of Hepatocyte Nuclear Factor-4α on the Regulation of the Hepatic Acute Phase Response Fulltext Access 13 Pages 2007
Structure-based Protocol for Identifying Mutations that Enhance Protein–Protein Binding Affinities Fulltext Access 13 Pages 2007
Bile Acid Interactions with Rabbit Ileal Lipid Binding Protein and an Engineered Helixless Variant Reveal Novel Ligand Binding Properties of a Versatile β-Clam Shell Protein Scaffold Fulltext Access 13 Pages 2007
Ligand Binding and Activation in a Prokaryotic Cyclic Nucleotide-modulated Channel Fulltext Access 13 Pages 2007
Substrate-induced Conformational Changes and Dynamics of UDP-N-Acetylgalactosamine:Polypeptide N-Acetylgalactosaminyltransferase-2 Fulltext Access 13 Pages 2007
Single MHC Mutation Eliminates Enthalpy Associated with T Cell Receptor Binding Fulltext Access 13 Pages 2007
The Crystal Structure of the Dps2 from Deinococcus radiodurans Reveals an Unusual Pore Profile with a Non-specific Metal Binding Site Fulltext Access 13 Pages 2007
Axial Coordination of Heme in Ferric CcmE Chaperone Characterized by EPR Spectroscopy Fulltext Access 13 Pages 2007
The Arginine Methyltransferase CARM1 Regulates the Coupling of Transcription and mRNA Processing Fulltext Access 13 Pages 2007
Human Cancer Cells Harbor T-Stumps, a Distinct Class of Extremely Short Telomeres Fulltext Access 13 Pages 2007
U2 snRNP Binds Intronless Histone Pre-mRNAs to Facilitate U7-snRNP-Dependent 3′ End Formation Fulltext Access 13 Pages 2007
How Integration of Positive and Negative Regulatory Signals by a STAND Signaling Protein Depends on ATP Hydrolysis Fulltext Access 13 Pages 2007
Evolutionarily Conserved Multisubunit RBL2/p130 and E2F4 Protein Complex Represses Human Cell Cycle-Dependent Genes in Quiescence Fulltext Access 13 Pages 2007
A Critical Role for the Ubiquitin-Conjugating Enzyme Ubc13 in Initiating Homologous Recombination Fulltext Access 13 Pages 2007
Transcriptional Activation of miR-34a Contributes to p53-Mediated Apoptosis Fulltext Access 13 Pages 2007
Purification of a Plant Mediator from Arabidopsis thaliana Identifies PFT1 as the Med25 Subunit Fulltext Access 13 Pages 2007
TNF-Induced Activation of the Nox1 NADPH Oxidase and Its Role in the Induction of Necrotic Cell Death Fulltext Access 13 Pages 2007
Evidence for an Adaptation Mechanism of Mitochondrial Translation via tRNA Import from the Cytosol Fulltext Access 13 Pages 2007
Unconventional Mechanism of mRNA Capping by the RNA-Dependent RNA Polymerase of Vesicular Stomatitis Virus Fulltext Access 13 Pages 2007
Orientation and Dynamics of Melittin in Membranes of Varying Composition Utilizing NBD Fluorescence Fulltext Access 13 Pages 2007
Insight into the Putative Specific Interactions between Cholesterol, Sphingomyelin, and Palmitoyl-Oleoyl Phosphatidylcholine Fulltext Access 13 Pages 2007
Natural MHC Class I Polymorphism Controls the Pathway of Peptide Dissociation from HLA-B27 Complexes Fulltext Access 13 Pages 2007
Thermal Response of Langmuir-Blodgett Films of Dipalmitoylphosphatidylcholine Studied by Atomic Force Microscopy and Force Spectroscopy Fulltext Access 13 Pages 2007
Spectroscopic and Structural Study of Proton and Halide Ion Cooperative Binding to GFP Fulltext Access 13 Pages 2007
Role of a Conserved Salt Bridge between the PAS Core and the N-Terminal Domain in the Activation of the Photoreceptor Photoactive Yellow Protein Fulltext Access 13 Pages 2007
Flexible interaction of Drosophila Smad complexes with bipartite binding sites Fulltext Access 13 Pages 2007
Sphingosine kinase 1 expression is regulated by signaling through PI3K, AKT2, and mTOR in human coronary artery smooth muscle cells Fulltext Access 13 Pages 2007
Transcriptional and epigenetic regulation of the integrin collagen receptor locus ITGA1-PELO-ITGA2 Fulltext Access 13 Pages 2007
ATF-2 stimulates the human insulin promoter through the conserved CRE2 sequence Fulltext Access 13 Pages 2007
Adjacent Residues in the E1 Initiator β-Hairpin Define Different Roles of the β-Hairpin in Ori Melting, Helicase Loading, and Helicase Activity Fulltext Access 13 Pages 2007
p73 Suppresses Polyploidy and Aneuploidy in the Absence of Functional p53 Fulltext Access 13 Pages 2007
A Histone H2A Deubiquitinase Complex Coordinating Histone Acetylation and H1 Dissociation in Transcriptional Regulation Fulltext Access 13 Pages 2007
Methylation of a Histone Mimic within the Histone Methyltransferase G9a Regulates Protein Complex Assembly Fulltext Access 13 Pages 2007
The 5′ End of U2 snRNA Is in Close Proximity to U1 and Functional Sites of the Pre-mRNA in Early Spliceosomal Complexes Fulltext Access 13 Pages 2007
Cdc48pNpl4p/Ufd1p Binds and Segregates Membrane-Anchored/Tethered Complexes via a Polyubiquitin Signal Present on the Anchors Fulltext Access 13 Pages 2007
Identification of FAAP24, a Fanconi Anemia Core Complex Protein that Interacts with FANCM Fulltext Access 13 Pages 2007
Identification of Two Distinct Hybrid State Intermediates on the Ribosome Fulltext Access 13 Pages 2007
Integration of Phosphoinositide- and Calmodulin-Mediated Regulation of TRPC6 Fulltext Access 13 Pages 2007
Control of Macroautophagy by Calcium, Calmodulin-Dependent Kinase Kinase-β, and Bcl-2 Fulltext Access 13 Pages 2007
A Conserved Docking Site Modulates Substrate Affinity for Calcineurin, Signaling Output, and In Vivo Function Fulltext Access 13 Pages 2007
Crystal Structure of Murine CstF-77: Dimeric Association and Implications for Polyadenylation of mRNA Precursors Fulltext Access 13 Pages 2007
Roles of dynamic and reversible histone acetylation in plant development and polyploidy Fulltext Access 13 Pages 2007
Nucleosome Chiral Transition under Positive Torsional Stress in Single Chromatin Fibers Fulltext Access 13 Pages 2007
E2F Activation of S Phase Promoters via Association with HCF-1 and the MLL Family of Histone H3K4 Methyltransferases Fulltext Access 13 Pages 2007
Scm3 Is Essential to Recruit the Histone H3 Variant Cse4 to Centromeres and to Maintain a Functional Kinetochore Fulltext Access 13 Pages 2007
Sealing of Chromosomal DNA Nicks during Nucleotide Excision Repair Requires XRCC1 and DNA Ligase IIIα in a Cell-Cycle-Specific Manner Fulltext Access 13 Pages 2007
The MUC1 and Galectin-3 Oncoproteins Function in a MicroRNA-Dependent Regulatory Loop Fulltext Access 13 Pages 2007
Structural and Functional Insights into Dom34, a Key Component of No-Go mRNA Decay Fulltext Access 13 Pages 2007
An Interlocked Dimer of the Protelomerase TelK Distorts DNA Structure for the Formation of Hairpin Telomeres Fulltext Access 13 Pages 2007
Structural and Functional Characterization of Human Telomerase RNA Processing and Cajal Body Localization Signals Fulltext Access 13 Pages 2007