Pre-trial evaluation of the potential for unblinding in drug trials: A prototype example Fulltext Access 10 Pages 2005
The Validation of Patient-Rated Global Assessments of Treatment Benefit, Satisfaction, and Willingness to Continue-The BSW Fulltext Access 10 Pages 2005
Functional Assessment in Migraine (FAIM) Questionnaire: Development of an Instrument Based Upon the WHO's International Classification of Functioning, Disability, and Health Fulltext Access 10 Pages 2005
The Routine Collation of Health Outcomes Data from Hospital Treated Subjects in the Health Outcomes Data Repository (HODaR): Descriptive Analysis from the First 20,000 Subjects Fulltext Access 10 Pages 2005
Obesity, Survival, and Hospital Costs-Findings from a Screening Project in Sweden Fulltext Access 10 Pages 2005
Determinación y utilización de la concentración plasmática de homocisteÃna en la práctica clÃnica Fulltext Access 10 Pages 2005
Patent Foramen Ovale: The Missing Link between Deep Venous Thrombotic Disease and Embolic Stroke Fulltext Access 10 Pages 2005
Economic and Utilization Outcomes Associated with Choice of Treatment for Venous Thromboembolism in Hospitalized Patients Fulltext Access 10 Pages 2005
The Study of the Effects of Diet on Metabolism and Nutrition (STEDMAN) weight loss project: Rationale and design Fulltext Access 10 Pages 2005
An assessment of willingness to participate in a randomized trial of arthroscopic knee surgery in patients with osteoarthritis Fulltext Access 10 Pages 2005
A Bayesian evaluation of enrolling additional patients at the maximum tolerated dose in Phase I trials Fulltext Access 10 Pages 2005
Practical applications of usability theory to electronic data collection for clinical trials Fulltext Access 10 Pages 2005
Can keeping clinical trial participants blind to their study treatment adversely affect subsequent care? Fulltext Access 10 Pages 2005
Estimating live birth rates after ovulation induction in polycystic ovary syndrome: Sample size calculations for the pregnancy in polycystic ovary syndrome trial Fulltext Access 10 Pages 2005
The Use of Decision Analytic Models to Inform Clinical Decision Making in the Management of Hepatocellular Carcinoma Fulltext Access 10 Pages 2005
1H NMR studies of homo and mixed ligand complexes of Tl+ ion with several polyazamacrocycles Fulltext Access 10 Pages 2005
Design, development and synthesis of mixed bioconjugates of piperic acid-glycine, curcumin-glycine/alanine and curcumin-glycine-piperic acid and their antibacterial and antifungal properties Fulltext Access 10 Pages 2005
Cytotoxic and antitumoral properties in a series of new, ring D modified, olivacine analogues Fulltext Access 10 Pages 2005
Berberine, a strong polyriboadenylic acid binding plant alkaloid: spectroscopic, viscometric, and thermodynamic study Fulltext Access 10 Pages 2005
Facile synthesis of the heptasaccharide repeating unit of O-deacetylated GXM of C. neoformans serotype B Fulltext Access 10 Pages 2005
The discovery and preparation of disubstituted novel amino-aryl-piperidine-based renin inhibitors Fulltext Access 10 Pages 2005
Synthesis, biological evaluation and molecular modelling studies on benzothiadiazine derivatives as PDE4 selective inhibitors Fulltext Access 10 Pages 2005
Synthesis and antiviral activity of novel acyclic nucleosides in the 5-alkynyl- and 6-alkylfuro[2,3-d]pyrimidine series Fulltext Access 10 Pages 2005
Antimycobacterial compounds. Optimization of the BM 212 structure, the lead compound for a new pyrrole derivative class Fulltext Access 10 Pages 2005
Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current Fulltext Access 10 Pages 2005
QSTR with extended topochemical atom indices. Part 5: Modeling of the acute toxicity of phenylsulfonyl carboxylates to Vibrio fischeri using genetic function approximation Fulltext Access 10 Pages 2005
In vitro evaluation of the anti-estrogenic activity of hydroxyl substituted diphenylnaphthyl alkene ligands for the estrogen receptor Fulltext Access 10 Pages 2005
Optimization of a coagulation factor VIIa inhibitor found in factor Xa inhibitor library Fulltext Access 10 Pages 2005
Human telomerase inhibition and cytotoxicity of regioisomeric disubstituted amidoanthraquinones and aminoanthraquinones Fulltext Access 10 Pages 2005
Identification of the minimal glycopeptide core recognized by T cells in a model for rheumatoid arthritis Fulltext Access 10 Pages 2005
QSAR analyses on ginkgolides and their analogues using CoMFA, CoMSIA, and HQSAR Fulltext Access 10 Pages 2005
Cyclic sulfamide HIV-1 protease inhibitors, with sidechains spanning from P2/P2â² to P1/P1â² Fulltext Access 10 Pages 2005
Synthesis and structure-activity relationships of benzyloxyphenyl derivatives as a novel class of NCX inhibitors: effects on heart failure Fulltext Access 10 Pages 2005
Synthesis, biological evaluation, and molecular modeling of novel thioacridone derivatives related to the anticancer alkaloid acronycine Fulltext Access 10 Pages 2005
Role of soil microbes in the rhizospheres of plants growing on trace metal contaminated soils in phytoremediation Fulltext Access 10 Pages 2005
Biogeochemistry of selenium and its impact on food chain quality and human health Fulltext Access 10 Pages 2005
Zinc has ambiguous effects on chromium (VI)-induced oxidative stress and apoptosis Fulltext Access 10 Pages 2005
Effects of acute administration of ethanol on cerebral glucose utilization in adult alcohol-preferring and alcohol-nonpreferring rats Fulltext Access 10 Pages 2005
Ethanol-induced alterations in Rab proteins: possible implications for pituitary dysfunction Fulltext Access 10 Pages 2005
Structure–activity studies of uptake and phototoxicity with heavy-chalcogen analogues of tetramethylrosamine in vitro in chemosensitive and multidrug-resistant cells Fulltext Access 10 Pages 2005
Density-functional theory and ab initio Hartree–Fork studies on the structural parameters and chemical activity of the free radicals generated by benzoquinone and hydroquinone Fulltext Access 10 Pages 2005
Synthesis and antitumor evaluation of novel 5-substituted-4-hydroxy-8-nitroquinazolines as EGFR signaling-targeted inhibitors Fulltext Access 10 Pages 2005
Synthesis and antitrichinellosis activity of some 2-substituted-[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-ones Fulltext Access 10 Pages 2005
Design, synthesis, and biological characterization of potential antiatherogenic nitric oxide releasing tocopherol analogs Fulltext Access 10 Pages 2005
Synthesis and evaluation of bifunctional nitrocatechol inhibitors of pig liver catechol-O-methyltransferase Fulltext Access 10 Pages 2005
A cyclic PNA-based compound targeting domain IV of HCV IRES RNA inhibits in vitro IRES-dependent translation Fulltext Access 10 Pages 2005
Synthetic multifunctional pores that open and close in response to chemical stimulation Fulltext Access 10 Pages 2005
Design, synthesis, and biological evaluation of linear 1-(4-, 3- or 2-methylsulfonylphenyl)-2-phenylacetylenes: A novel class of cyclooxygenase-2 inhibitors Fulltext Access 10 Pages 2005
Homology modelling and active-site-mutagenesis study of the catalytic domain of the pneumococcal phosphorylcholine esterase Fulltext Access 10 Pages 2005
A new structural alternative in benzo[b]furans for antimicrobial activity Fulltext Access 10 Pages 2005
9-Oxime-3-ketolides: Modification at the C-11,12-diol moiety and antibacterial activities against key respiratory pathogens Fulltext Access 10 Pages 2005
Antitumor activity and distribution of pyrroloiminoquinones in the sponge genus Zyzzya Fulltext Access 10 Pages 2005
Synthesis and cytotoxicity of epoxide and pyrazole analogs of the combretastatins Fulltext Access 10 Pages 2005
Synthesis of 5-haloethynyl- and 5-(1,2-dihalo)vinyluracil nucleosides: Antiviral activity and cellular toxicity Fulltext Access 10 Pages 2005
Preparation of highly substituted γ-lactam follicle stimulating hormone receptor agonists Fulltext Access 10 Pages 2005
An anionic inositol phosphate glycan pseudotetrasaccharide exhibits high insulin-mimetic activity in rat adipocytes Fulltext Access 10 Pages 2005
Optimized N-phenyl-N′-(2-chloroethyl)ureas as potential antineoplastic agents: Synthesis and growth inhibition activity Fulltext Access 10 Pages 2005
Aza-bicyclic amino acid carboxamides as α4β1/α4β7 integrin receptor antagonists Fulltext Access 10 Pages 2005
Donepezil–tacrine hybrid related derivatives as new dual binding site inhibitors of AChE Fulltext Access 10 Pages 2005
Synthesis of arylidene-substituted gelastatin analogues and their screening for MMP-2 inhibitory activity Fulltext Access 10 Pages 2005
Identification of carbon-centred radicals derived from linalyl hydroperoxide, a strong skin sensitizer: a possible route for protein modifications Fulltext Access 10 Pages 2005
Combinatorial design of nonsymmetrical cyclic urea inhibitors of aspartic protease of HIV-1 Fulltext Access 10 Pages 2005
Properties and structure–activity studies of cyclic β-hairpin peptidomimetics based on the cationic antimicrobial peptide protegrin I Fulltext Access 10 Pages 2005
Cooperative lectin recognition of periodical glycoclusters along DNA duplexes: alternate hybridization and full hybridization Fulltext Access 10 Pages 2005
Synthesis of 9-alkyl and 9-heteroalkyl substituted 2-amino-6-guanidinopurines and their influence on the NO-production in macrophages Fulltext Access 10 Pages 2005
Synthesis and human NKT cell stimulating properties of 3-O-sulfo-α/β-galactosylceramides Fulltext Access 10 Pages 2005
Novel non-steroidal/non-anilide type androgen antagonists: discovery of 4-substituted pyrrole-2-carboxamides as a new scaffold for androgen receptor ligands Fulltext Access 10 Pages 2005
Design, synthesis, and biological evaluation of folic acid targeted tetraphenylporphyrin as novel photosensitizers for selective photodynamic therapy Fulltext Access 10 Pages 2005
3D-QSAR CoMFA studies on trypsin-like serine protease inhibitors: a comparative selectivity analysis Fulltext Access 10 Pages 2005
Design, synthesis, and structure–activity relationships of potent GPIIb/IIIa antagonists: discovery of FK419 Fulltext Access 10 Pages 2005
Combinatorial approach to identification of tyrphostin inhibitors of cytokine signaling Fulltext Access 10 Pages 2005
5-Arylidene-2-imino-4-thiazolidinones: Design and synthesis of novel anti-inflammatory agents Fulltext Access 10 Pages 2005
Synthesis of gossypol atropisomers and derivatives and evaluation of their anti-proliferative and anti-oxidant activity Fulltext Access 10 Pages 2005
O6-3-[125I]iodobenzyl-2′-deoxyguanosine ([125I]IBdG): synthesis and evaluation of its usefulness as an agent for quantification of alkylguanine-DNA alkyltransferase (AGT) Fulltext Access 10 Pages 2005
Methyltrioxorhenium: a new catalyst for the activation of hydrogen peroxide to the oxidation of lignin and lignin model compounds Fulltext Access 10 Pages 2005
Structural modification of phenylpropanoid-derived compounds and the effects on their participation in redox processes Fulltext Access 10 Pages 2005
Design, synthesis, and biological evaluation of N-acetyl-2-carboxybenzenesulfonamides: a novel class of cyclooxygenase-2 (COX-2) inhibitors Fulltext Access 10 Pages 2005
Zidampidine, an aryl phosphate derivative of AZT: in vivo pharmacokinetics, metabolism, toxicity, and anti-viral efficacy against hemorrhagic fever caused by Lassa virus Fulltext Access 10 Pages 2005
Improved synthesis of daunomycin conjugates with triplex-forming oligonucleotides. The polypurine tract of HIV-1 as a target Fulltext Access 10 Pages 2005
Dual DNA recognition codes of a short peptide derived from the basic leucine zipper protein EmBP1 Fulltext Access 10 Pages 2005
Novel cytotoxic monotetrahydrofuranic Annonaceous acetogenins from Annona montana Fulltext Access 10 Pages 2005
Furoxan analogues of the histamine H3-receptor antagonist imoproxifan and related furazan derivatives Fulltext Access 10 Pages 2005
Design, modelling, synthesis and biological evaluation of peptidomimetic phosphinates as inhibitors of matrix metalloproteinases MMP-2 and MMP-8 Fulltext Access 10 Pages 2005
Design, synthesis, and biological evaluation of N-acetyl-2-(or 3-)carboxymethylbenzenesulfonamides as cyclooxygenase isozyme inhibitors Fulltext Access 10 Pages 2005