Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10588741 | Bioorganic & Medicinal Chemistry Letters | 2011 | 6 Pages |
Abstract
The synthesis and SAR of a series of 4,4-disubstituted cyclohexylbenzamide inhibitors of 11β-HSD1 are described. Optimization rapidly led to potent, highly selective, and orally bioavailable inhibitors demonstrating efficacy in both rat and non-human primate ex vivo pharmacodynamic models.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Daqing Sun, Zhulun Wang, Seb Caille, Michael DeGraffenreid, Felix Gonzalez-Lopez de Turiso, Randall Hungate, Juan C. Jaen, Ben Jiang, Lisa D. Julian, Ron Kelly, Dustin L. McMinn, Jacob Kaizerman, Yosup Rew, Athena Sudom, Hua Tu, Stefania Ursu,