| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10593557 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
Novel oxazolidinedione analogs were discovered as potent and selective mineralocorticoid receptor (MR) antagonists. Structure-activity relationship (SAR) studies were focused on improving the potency and microsomal stability. Selected compounds demonstrated excellent MR activity, reasonable nuclear hormone receptor selectivity, and acceptable rat pharmacokinetics.
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Authors
Christine Yang, Hong C. Shen, Zhicai Wu, Hong D. Chu, Jason M. Cox, Jaume Balsells, Alejandro Crespo, Patricia Brown, Beata Zamlynny, Judyann Wiltsie, Joseph Clemas, Jack Gibson, Lisa Contino, JeanMarie Lisnock, Gaochao Zhou, Margarita Garcia-Calvo,