Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10594813 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
Inhibition of the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway is one of the most intensively studied approaches to cancer therapy. Rational design led to the identification of novel 7-amino-5-methyl-1,6-naphthyridin-2(1H)-one derivatives as potent PI3K/mTOR dual inhibitors. Design, synthesis and structure activity relationship are reported.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Songwen Lin, Fangbin Han, Peng Liu, Jing Tao, Xuechao Zhong, Xiujie Liu, Chongqin Yi, Heng Xu,