| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595606 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
A series of tetrahydroquinoline-derived inhibitors of the CRTH2 receptor was discovered by a high throughput screen. Optimization of these compounds for potency and pharmacokinetic properties led to the discovery of potent and orally bioavailable CRTH2 antagonists.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jiwen Liu, Yingcai Wang, Ying Sun, Derek Marshall, Shichang Miao, George Tonn, Penny Anders, Joel Tocker, H. Lucy Tang, Julio Medina,