Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10870152 | FEBS Letters | 2014 | 8 Pages |
Abstract
Fibrillins form multifunctional microfibrils in most connective tissues. Deficiencies in fibrillin assembly can result in fibrillinopathies, such as Marfan syndrome. We demonstrate the presence of heparin/heparan sulfate binding sites in fibrillin-2 and -3. Multimerization of all three fibrillins drastically increased the apparent affinity of their interaction with heparin/heparan sulfate. Surprisingly, contrary to other reports heparin/heparan sulfate strongly inhibited homo- and heterotypic N-to-C-terminal fibrillin interactions. These data suggest that heparin/heparan sulfate controls the formation of microfibrils at the bead interaction stage.
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Authors
Laetitia Sabatier, Jelena Djokic, Dirk Hubmacher, Dzaner Dzafik, Valentin Nelea, Dieter P. Reinhardt,