Three new pyrrolizidine alkaloids derivatives from Liparis nervosa

Three new pyrrolizidine alkaloids, nervosine VII (1), nervosine VIII (2) and nervosine IX (3) were isolated from the whole plant extract of Liparis nervosa. Their structures were elucidated by extensive spectroscopic analyses (including 1D, 2D NMR, and HR-ESI-MS) and chemical methods. Compounds 1–3 were evaluated for their cytotoxic activity against A549, MCF-7and H460 human cancer cell lines.

Graphical abstractThree new pyrrolizidine alkaloids were isolated from Liparis nervosa. Their structures were elucidated on the basis of extensive spectroscopic analysis. All compounds isolated were evaluated for their cytotoxic activity against A549, MCF-7and H460 human cancer cell lines.Figure optionsDownload full-size imageDownload as PowerPoint slide