Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1253987 | Chinese Chemical Letters | 2016 | 6 Pages |
A facile synthesis for cyanochlorin related to chlorophyll from a formyl-substituted chlorin, by the oxidation of methyl (pyro)pheophorbide-a, was accomplished. These readily available chlorin aldehydes were assembled together with hydroxylamine hydrochloride in a tandem process to produce the corresponding chlorin nitriles in moderate to good yields. The formation of chlorin nitrile was discussed and a possible mechanism for the corresponding cyanation reaction was tentatively proposed.
Graphical abstractA facile synthesis for cyano-chlorin related to chlorophyll from a formyl-substituted chlorin, prepared by the oxidation of methyl (pyro)pheophorbide-a, was accomplished by a tandem reaction.Figure optionsDownload full-size imageDownload as PowerPoint slide