Synthesis of 1,2,3-benzotriazin-4-one derivatives containing spirocyclic indoline-2-one moieties and their nematicidal evaluation

To discover new chemotypes of nematicides with proper toxicological profiles, a series of novel 1,2,3-benzotriazin-4-one derivatives were synthesized and further bioevaluated. The bioassay results showed that most of the synthesized compounds were endowed with moderate to good control efficacy against Meloidogyne incognita at 10.0 mg/L in vivo. Among them, compounds 6k and 6p displayed 100% inhibitory activities at this concentration, which implied that they could be used as lead compounds for promising nematicides.

Graphical abstract1,2,3-Benzotriazin-4-one derivatives containing spirocyclic indoline-2-one moieties were designed, synthesized and bioevaluated against Meloidogyne incognita. Some of them exhibited good nematicidal activities, up to 100% at 10.0 mg/L.Figure optionsDownload full-size imageDownload as PowerPoint slide