Y(OTf)3-catalyzed heterocyclic formation via aerobic oxygenation: An approach to dihydro quinazolinones and quinazolinones

The Y(OTf)3-catalyzed aerobic oxidative cyclization reaction for the selective synthesis of dihydroquinazolinones and quinazolinones has been developed. This method provides a practical, effective and green synthetic approach to dihydroquinazolinones and quinazolinones which both are important units in many biologically active compounds.

Graphical abstractThis method provides a green and efficient method to selectively synthesize dihydroquinazolinones and quinazolinones catalyzed by Y(OTf)3. The usage of molecular oxygen in air renders this protocol very attractive and practical.Figure optionsDownload full-size imageDownload as PowerPoint slide