Folate binding protein—Outlook for drug delivery applications

Serum proteins represent an important class of drug and imaging agent delivery vectors. In this mini-review, key advantages of using serum proteins are discussed, followed by the particular advantages and challenges associated with employing soluble folate binding protein. In particular, approaches employing drugs that target folate metabolism are reviewed. Additionally, the slow-onset, tight-binding interaction of folate with folate binding protein and the relationship to a natural oligomerization mechanism is discussed. These unique aspects of folate binding protein suggest interesting applications for the protein as a vector for further drug and imaging agent development.

Graphical abstractThe proposed formation of a “dragon ball” therapeutic based upon a functionalized folic acid initiator combined with the natural oligomerization of folate binding protein.Figure optionsDownload full-size imageDownload as PowerPoint slide