Synthesis of new 4,6-diaryl-2-(arylthio)nicotinonitriles in Triton X-100 aqueous micellar media

In this communication, we report four component condensations of acetophenone, arylaldehydes, arylthiol, and malononitrile in the presence of Triton X-100 (5 mol%) aqueous micelles. This reaction led to the formation of 4,6-diaryl-2-(arylthio)nicotinonitrile new derivatives in good yields. The FT-IR, 19F NMR, 1H NMR, 13C NMR spectra and elemental analysis confirm the structure of compounds.

Graphical abstractIn this communication, we report four component condensations of acetophenone, arylaldehydes, arylthiol, and malononitrile in the presence of Triton X-100 (5 mol%) aqueous micelles. This reaction led to the formation of 4,6-diaryl-2-(arylthio)nicotinonitrile new derivatives in good yields.Figure optionsDownload full-size imageDownload as PowerPoint slide