Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1254116 | Chinese Chemical Letters | 2014 | 4 Pages |
A simple and efficient procedure was developed for the synthesis of 11H(2H)-4-oxothiophene[3′,4′:6,5]pyrido[3,2-a]azulene-10-carboxylates (3) in moderate to good yields via the Gewald reaction of ethyl 1-cyanoacetyl-2-methoxyazulene-3-carboxylate (1) with carbonyl compounds (2) and elemental sulfur utilizing imidazole as catalyst. This reaction provides a new procedure for synthesis of pyridinone-fused azulenes.
Graphical abstractA simple and efficient procedure was developed for the synthesis of 11H(2H)-4-oxothiophene[3′,4′:6,5]pyrido[3,2-a]azulene-10-carboxylates (3) in moderate to good yields via Gewald reaction of ethyl 1-cyanoacetyl-2-methoxyazulene-3-carboxylate (1) with carbonyl compounds (2) and elemental sulfur utilizing imidazole as catalyst. This reaction provides a new procedure for synthesis of pyridinone-fused azulenes.Figure optionsDownload full-size imageDownload as PowerPoint slide