One-pot synthesis of novel pyrido[2,3-d]pyrimidines using HAp-encapsulated-γ-Fe2O3 supported sulfonic acid nanocatalyst under solvent-free conditions

Novel pyrido[2,3-d]pyrimidine derivatives were synthesized through a one-pot three-component approach using HAp-encapsulated-γ-Fe2O3 [γ-Fe2O3@HAp-SO3H] catalyzed condensation of 6-amino-2-(methylthio or ethylthio)pyrimidin-4(3H)-one, Meldrum's acid and aryl aldehydes at 60 °C and under solvent-free conditions. In this protocol the use of nanocatalyst provided a green, useful and rapid method to generate the products in short reaction times and excellent yields (88%–94%).

Graphical abstractA one-pot synthesis of pyrido[2,3-d]pyrimidine derivatives (4a–n) in the presence of [γ-Fe2O3@HAp-SO3H] as a nanocatalyst at 60 °C under solvent-free conditions is described.Figure optionsDownload full-size imageDownload as PowerPoint slide