SrCl2 as an efficient cocatalyst for acidic hydrolysis of methyl glycosides

SrCl2 was found to be the most efficient cocatalyst for the acidic hydrolysis of methyl glycosides after 26 kinds of most representative metal salts were screened. The SrCl2-cocatalyzed acidic hydrolysis of methyl glycosides is highlighted by short reaction times, less byproducts and high yields. A possible mechanism for the SrCl2-cocatalyzed hydrolysis is also proposed.

Graphical abstractSrCl2 was found to be the most efficient cocatalyst for the acidic hydrolysis of methyl glycosides among 26 metal salts screened as Lewis acid. The SrCl2-cocatalyzed acidic hydrolysis of methyl glycosides was highlighted by short reaction times, less byproducts and high yields, and was applicable to a variety of methyl glycosides, especially to those with O-benzyl protecting groups.Figure optionsDownload full-size imageDownload as PowerPoint slide