A green multicomponent synthesis of bioactive pyrimido[4,5-b]quinoline derivatives as antibacterial agents in water catalyzed by RuCl3·xH2O

An efficient, convenient and environmentally benign one-pot multicomponent reaction for the preparation of pyrimido[4,5-b]quinoline derivatives as biologically, pharmacologically and antibacterially active products has been developed using RuCl3·xH2O as a reusable homogenous catalyst. Use of water as a green solvent, purification of products by non-chromatographic methods, reusability of transition metal homogenous catalyst, saving energy by employing multicomponent reactions, short reaction times and high yields, are some of the advantages of this process.

Graphical abstractRuCl3·xH2O, as a homogenous and reusable catalyst, has been used as an efficient and powerful catalyst for the synthesis of pyrimido[4,5-b]quinoline derivatives.Figure optionsDownload full-size imageDownload as PowerPoint slide