Formal synthesis of (+)-tashiromine and study toward the total synthesis of (+)-stemoamide

An efficient formal synthesis of (+)-tashiromine was achieved by employing an intermolecular asymmetric Mannich-type reaction as the key step. Concurrently, a novel approach toward the total synthesis of (+)-stemoamide through dyotropic rearrangement of 3,4-cis-β-lactone was also explored.

Graphical abstractA formal synthesis of (+)-tashiromine was achieved concisely, and a novel synthetic approach toward (+)-stemoamide via dyotropic rearrangement of β-lactone was also explored.Figure optionsDownload full-size imageDownload as PowerPoint slide