Synthesis of novel 1,3-oxazole derivatives with insect growth-inhibiting activities

Straightforward and direct synthesis of 2-substituted-5-oxazolecarbaldehydes was achieved by treating propargylamides with mercury(II) perchlorate as catalyst and ammonium cerium(IV) nitrate as oxidant agent through intramolecular cyclization. These structurally interesting outcomes benefit to synthesize 2,5-disubstituted-1,3-oxazoles with armyworm growth regulating activities.

Graphical abstractA series of novel 1,3-oxazole derivatives with insect growth-inhibiting activities against armyworm were synthesized by a mercury(II) catalyzed intramolecular cyclization reaction as key step.Figure optionsDownload full-size imageDownload as PowerPoint slide