Magnetically recyclable copper modified GO/Fe3O4 catalyst for efficient synthesis of quinazolinones

A series of bioactive quinazolinones were effectively synthesized by the condensation of halide benzamide with amino acid using magnetically recyclable GO/Fe3O4–CuI as catalyst. Magnetic GO/Fe3O4–CuI was prepared via a simple chemical method and characterized by FTIR, powder XRD, and SEM. This heterogeneous copper catalyst can be easily separated from reaction mixtures by an external permanent magnet and reused without any obvious loss in activity which shows its applicability as a reusable and promising catalyst for quinazolinones synthesis.

Graphical abstractA series of bioactive quinazolinones were effectively synthesized by the condensation of halide benzamide with amino acid using magnetically separable and reusable GO/Fe3O4–CuI as catalyst.Figure optionsDownload full-size imageDownload as PowerPoint slide