Article ID Journal Published Year Pages File Type
1254309 Chinese Chemical Letters 2016 5 Pages PDF
Abstract

A series of 1,5-diaryl-1,4-pentadien-3-one derivatives bearing an emodin group were designed and synthesized by the combination of natural products. The antiviral activities against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV) in vivo were evaluated. Some of the derivatives displayed promising curative effect and protective activity against TMV. Compound D5 showed appreciable curative bioactivity on TMV approximately of 50% at 306.2 μg/mL, which was superior to ningnanmycin (409.3 μg/mL).

Graphical abstractA series of 1,5-diaryl-1,4-pentadien-3-one derivatives were synthesized by combining two structures of natural products. Some of the target compounds exhibited moderate to excellent antiviral activity against tobacco mosaic virus (TMV).Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Chemistry (General)
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