Propylphosphonic anhydride (T3P®) catalyzed one-pot synthesis of α-aminonitriles

The Strecker reaction was performed via a one-pot three component condensation of hetero aromatic/aromatic aldehydes, secondary amines and trimetylsilyl cyanide in the presence of propylphosphonic anhydride (T3P®) to accomplish the corresponding α-aminonitriles. The main advantages of this method are very short reaction time and excellent yields.

Graphical abstractStrecker reaction was applied to the novel synthesis of α-aminonitriles from hetero-aromatic and aromatic aldehydes in a one-pot three-component reaction using catalytic propylphosphonic anhydride. The reaction was carried out at room temperature with short reaction time and excellent yields.Figure optionsDownload full-size imageDownload as PowerPoint slide