Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1254427 | Chinese Chemical Letters | 2012 | 4 Pages |
Abstract
The synthesis and biological evaluation of two series of salicylanilide derivatives on the EGFR and ErbB-2 tyrosine kinases inhibitory activities were conducted. Of the tested compounds those having an additional aryl group substituted on the anilino ring were active on the EGFR tyrosine kinase inhibition (7a–c and 13a, 13c, 13d, 13f). The inhibitory activities were all in the low micromolar or submicromolar range. In addition, compound 13a was found to have dual inhibitory activities both on EGFR and ErbB-2 tyrosine kinases (1.654 ± 1.280 and 7.134 ± 1.265 μmol/L).
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Authors
Ning Ding, Wei Zhang, Hua Ling Xiao, Peng Wang, Ying Xia Li,