A novel and efficient strategy involving a CuI catalyzed cascade reaction to synthesize acenaphtho[1,2-b]quinoline derivatives

A novel and efficient approach for the straightforward synthesis of biologically significant acenaphtho[1,2-b]quinoline derivatives in good yields utilizing CuI as a catalyst with a broad array of substrates has been developed. The strategy features as a CuI-catalyzed cascade reaction involving the formation of two new CC bonds and one new CN bond with high atom economy. A proposed mechanism for the reaction is described.

Graphical abstractA novel and efficient approach for the straightforward synthesis of biologically significant acenaphtho[1,2-b]quinoline derivatives in the presence of CuI as a catalyst in good yield with a broad substrate scope has been developed.Figure optionsDownload full-size imageDownload as PowerPoint slide