Article ID Journal Published Year Pages File Type
1254469 Chinese Chemical Letters 2016 4 Pages PDF
Abstract

A chemoselective synthesis of novel indolizine derivatives were reported via three-component reactions of aminopyridines, acetylenic diesters and α-halo ketones. In these reactions, the zwitterion generated from aminopyridines and acetylenic diesters reacted with α-halo ketones to produce indolizine skeleton in good to high yields under mild reaction conditions.

Graphical abstractThree-component reactions of pyridines and dialkyl acetylenedicarboxylates with different α-halo ketones led to chemoselective synthesis of functionalized indolizines in good to high yields under mild reaction conditions. All the reactions gave the desired indolizines without formation of any [1,3]-oxazines.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Chemistry (General)
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