| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1254563 | Chinese Chemical Letters | 2016 | 5 Pages |
A series of bioactive bis(indolyl)methanes are synthesized by one-pot green reaction of indole with various substituted aldehydes by microwave irradiation under solvent free conditions. The antibacterial activity against Staphylococcus aureus and anti-inflammatory activity of the synthesized bis(indolyl)methanes are evaluated in vitro and compared to standard drugs tetracycline and diclofenac, respectively. The majority of the compounds showed good antibacterial and anti-inflammatory activity. Interestingly, compounds 3j, 3i, 3k and 3g exhibited much higher anti-inflammatory activity than the standard diclofenac drug and thus qualify for clinical trials to be used as an anti-inflammatory compound.
Graphical abstractA facile and clean one pot two component reaction of an aldehyde and indole in 1:2 molar ratio is described for the synthesis of bis(indolyl)methanes under microwave irradiation and catalytic free condition.Figure optionsDownload full-size imageDownload as PowerPoint slide
