Base mediated direct C–H amination for pyrimidines synthesis from amidines and cinnamaldehydes using oxygen as green oxidants

A direct metal-free C–H amination reaction of cinnamaldehydes and amidines to realize the synthesis of polysubstituted pyrimidines was developed in the presence of base. This greener synthetic methodology provides a straightforward approach to the synthesis of a variety of pyrimidine derivatives under mild reaction condition using oxygen as sole oxidants.

Graphical abstractA base mediated direct C–H amination for pyrimidines synthesis from amidines and cinnamaldehydes was developed using oxygen as green oxidants.Figure optionsDownload full-size imageDownload as PowerPoint slide