Codonopiloneolignanin A, a polycyclic neolignan with a new carbon skeleton from the roots of Codonopsis pilosula

A neolignan codonopiloneolignanin A (1) with a novel 2,9:2ʹ,9:7,7ʹ-tricyclo-8,9ʹ-neolignane skeleton was isolated from an aqueous extract of the Codonopsis pilosula roots. Its structure including the absolute configuration was elucidated by extensive spectroscopic analysis, including 2D NMR and electronic circular dichroism calculation. The proposed biosynthetic pathway of compound 1 is also discussed.

Graphical abstractCodonopiloneolignanin A (1), a neolignan with a novel 2,9:2ʹ,9:7,7ʹ-tricyclo-8,9ʹ-neolignane skeleton was isolated from an aqueous extract of the Codonopsis pilosula roots. Its structure including the absolute configuration was elucidated by extensive spectroscopic analysis, including 2D NMR and electronic circular dichroism calculation. The biosynthetic pathway of compound 1 is proposed.Figure optionsDownload full-size imageDownload as PowerPoint slide