A convergent approach to the tetracyclic core of atisane diterpenes

Atisane diterpenes are biologically interesting natural products. We report here a convergent approach to construct the tetracyclic core of the atisane skeleton. The two segments were assembled through a Wittig reaction, while an intramolecular Aldol condensation served as the key step to furnish the tetracyclic skeleton.

Graphical abstractThe convergent approach to the tetracyclic core of atisane diterpenes have been reported, which is a complement of the existing strategies for the synthesis of this type of natural products.Figure optionsDownload full-size imageDownload as PowerPoint slide